Mice who got nanosponge injections survived lethal doses of toxins.
Nanosponge Engineers at the University of California, San Diego have invented a "nanosponge" capable of safely removing a broad class of toxins from the bloodstream, including toxins produced by MRSA, E. Coli, poisonous snakes and bees. The nanosponges are made of a biocompatible polymer core wrapped in a natural red blood cell membrane. Zhang Research Lab
This is especially interesting because a nanosponge can work on entire classes of toxins. Most antidotes or treatments against venom, bioweapons or bacteria are targeted to counteract a specific molecular structure, so they can’t be a one-size-fits-all solution; this nanosponge can.
Scientists led by Liangfang Zhang, a nanoengineering professor at UCSD, worked with a class of proteins known as pore-forming toxins, which work just the way they sound: By ripping a hole in a cell membrane. These toxins are found in snake venom, sea anemones, and even bacteria like the dreaded drug-resistant Staph aureus. The proteins come in many different shapes and sizes, but they all work in a similar way.
They injected mice with 70 times as many toxic proteins as nanosponges, and the sponges still neutralized the poison and caused no visible damage to the animals, the team reports. Next up are clinical trials in animals, to verify that it works safely in a wide range of cases.
The paper is in this week's issue of Nature Nanotechnology.